Precision Medicines for Bacterial Infections and Microbiome Diseases

Precision Medicines for Bacterial Infections and Microbiome Diseases

Locus is developing powerful, precision medicines designed to combat the growing antimicrobial resistance (AMR) pandemic and treat diseases of the microbiome.

Precision Medicines for Bacterial Infections and Microbiome Diseases

First Patient Treated in the ELMINATE Registrational Phase 2/3 Trial of LBP-EC01 for UTIs

Worldwide, an estimated 150 million people are affected by UTIs each year. The high prevalence of E. coli (80%), high rate of recurrence (40%), and growing rate of antimicrobial resistance to commonly used antibiotics (>25%) epitomizes the growing need for patients experiencing these infections. LBP-EC01 is engineered to meet these needs.

Locus Biosciences Eliminate
Combatting The Antimicrobial Resistance Pandemic

Combatting The Antimicrobial Resistance Pandemic

In 2019 Antimicrobial Resistance (AMR) was directly responsible for >1.2 million deaths. Since the COVID-19 pandemic, misuse and overuse of antibiotics coupled with overrun healthcare systems have sent infection and resistance rates skyrocketing. The Locus Biopharmaceutical Development platform was purpose built to take this challenge head-on.

Help Us Change The Future of Medicine

Help Us Change The Future of Medicine

We are on a mission to revolutionize the treatment of disease. We need intelligent, open, hard-working people who thrive in a fast-paced environment to join us on our quest.

The Human
Microbiome


A collection of all the microbes that live on or in the human body, the microbiome plays an important role in your health. Day-to-day your microbiome helps digest your food, produce vitamins, regulate your immune system, and protect against other microbes that cause disease.

When the balance is disrupted, problematic microbes can take hold and cause or exacerbate: 

  • Infections like urinary tract infections (UTIs)
  • Immunologic diseases like inflammatory bowel disease (IBD)
  • Various types of cancer

Locus Biosciences builds precision medicines that target microbiome and address the unmet needs across bacterial infections, immunologic disorders, and cancer. 

The Human Microbiome

LOCUS
BIOPHARMACEUTICAL
DEVELOPMENT

Locus Biosciences has built the world’s most powerful platform to selectively remove pathogenic bacterial species from the human body while leaving the many species of “good” bacteria in the microbiome unaffected. Our products can also exploit bacteria in the microbiome to produce therapeutics that may be beneficial in treating a variety of diseases.

Locus Biomanufacturing Solutions

LOCUS
BIOMANUFACTURING
SOLUTIONS

Locus Biosciences has built a world-class biologics manufacturing facility—recognized by the International Society for Pharmaceutical Engineering (ISPE) in 2021 with its prestigious “Facility of the Year” award—to enable GMP manufacturing of its precision therapeutics.

Locus Biopharmaceutical Development
in signed deals

975 M

in signed deals

>1,000

bacteriophage engineered

4

programs targeting top global
MDR threats

LBP-EC01

LBP-EC01 is a precision therapeutic designed to target E. coli infections. More specifically, it is a cocktail of bacteriophages engineered to precisely remove E. coli in patients with urinary tract infections (UTIs).

LBP-PA01

LBP-PA01 is a precision therapeutic designed to target P. aeruginosa infections. Locus has partnered with Janssen Pharmaceuticals to develop this product. 

LBP-SA01

LBP-SA01 is a precision therapeutic designed to target S. aureus infections. Locus has partnered with Janssen Pharmaceuticals to develop this product.

LBP-KP01

LBP-KP01 is a precision therapeutic designed to target K. pneumoniae infections. Locus has partnered with the Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator (CARB-X) to develop this product.

IBD

Locus Biosciences is developing multiple approaches leveraging its Locus Biopharmaceutical Development platform to address both the pathogens and the resulting damage associated with Inflammatory Bowel Disease.

About Us

Locus Biosciences is a precision medicine company that is developing bacteriophage-based products to precisely remove pathogenic bacteria from the human body and to leverage the microbiome to treat diseases across multiple therapeutic areas.


Our Partners

We are supported by an exceptional team of partners across academia,
government, large pharma, and investors.

Artis Ventures
Barda
Viking
Tencent
NC State University
CARB-X
North Carolina Biotechnology Center
Johnson & Johnson Innovation | JJDC