About Locus Biosciences

Locus Biosciences is an emerging biotechnology company focused on the discovery and development of a next generation CRISPR-Cas platform for precision antimicrobials. Locus designs and creates novel applications that direct the powerful CRISPR-Cas3 nuclease to target and kill cells by irreversibly destroying DNA. Our platform enables the design and development of powerful antimicrobials that avoid currently known antibiotic resistance mechanisms while leaving non-target bacteria unharmed. Built on prokaryotic technology for prokaryotic targets, Locus is advancing its platform to create therapeutics for critical disease areas ranging from resistant bacterial infections to the microbiome.

Locus Biosciences is seeking highly motivated applicants to join our research and development team as a full-time Scientist. This position is well suited for innovative scientists that have a desire to lead their scientific efforts from the bench and a passion to develop and pursue multiple avenues to complete research objectives. This individual will work directly with our internal team and external collaborators to develop and deliver preclinical and platform development programs. The ideal candidate will have a significant record of accomplishment of having independently designed and implemented novel research approaches and prioritized multiple concurrent projects. This individual must be able to communicate effectively in formal and informal settings and be able to work well across interdisciplinary teams.  Candidates from various molecular biology, synthetic biology and microbial backgrounds are encouraged to apply.

Responsibilities will include:

  • Development of novel protocols and methods for assembling novel synthetic phage products
  • Independent management of multiple projects as both individual contributor and team lead
  • Development of high-throughput assays to further develop our genetic engineering platform
  • Implementation of appropriate statistical controls and analyses
  • Active engagement on overall experimental strategy and direction
  • Presentation of results to internal scientists, external collaborators, and Locus management
  • Close coordination with cross-functional teams

Candidate must possess:

  • A PhD in microbiology, microbial genetics, synthetic biology, genetic engineering or similar fields
  • Strong proficiency in microbial engineering (some combination of traditional or novel recombination techniques, high-throughput and next-generation DNA assembly, CRISPR, cloning, screening strategies, or high-throughput assay development)
  • Ability to structure, implement and maintain study plans in the face of ambiguity
  • Willingness to develop solutions to difficult objectives independently and consistently

Preferred qualifications:  

  • At least two years’ experience between postdoctoral or industry research
  • Experience with isolating, propagating and manipulating bacteriophages
  • Experience with genetically intractable or difficult-to-culture bacterial organisms
  • Detailed knowledge of infectious disease or microbiome, associated organisms and animal models
  • General understanding of the overall drug development lifecycle, especially preclinical phases
  • Experience with computational tools analyzing communities of microbes (16S, whole genome sequencing, metagenome sequencing, transcriptome sequencing, RNAseq) is highly desirable
  • Experience with automated and/or high-throughput processes is desirable

Job Type: Full-time

Job Location: Research Triangle Park, North Carolina

For immediate consideration, please email your resume or CV to: careers@locus-bio.com

Direct applicants only. No agencies please.

Locus Biosciences is seeking a highly motivated and entrepreneurial applicant to join our research and development team as a full-time Research Associate. This position is well suited for those that can apply accomplish defined work, as well as assist in approaching and solving complex scientific problems. This individual will be responsible for assisting in the generation, production and characterization of novel antimicrobial products. The ideal candidate will be able to independently conduct general microbiological and molecular biology research, and assist in the development of our broader research goals. This individual must be able to communicate effectively in formal and informal settings and be able to work well within a team. Candidates should have prior laboratory experience and be competent at basic molecular biology techniques.

Responsibilities will include:

  • Maintenance of bacterial cultures and stocks, viral stocks and other materials
  • Execution of studies to assemble, produce and characterize synthetic biology components
  • Preparation of technical reports and recommendations
  • Rapid acquisition of new skills and willingness to train other team members
  • Independent management of multiple projects as an individual contributor
  • Presentation of results to internal scientists
  • Close coordination within project teams

Candidate must possess:

  • A BS/ MS in microbiology, microbial genetics, synthetic biology, genetic engineering or similar fields
  • Familiarity with general laboratory techniques such as pipetting, plating bacterial cultures, serial dilutions, aseptic technique and proper decontamination procedures
  • Technical proficiency in molecular biology skills, such as DNA preparation, transformation, PCR, cloning, and plasmid construction
  • Experience with DNA sequence analysis, including homology searching, sequence assembly and primer design
  • Ability to independently carry out experiments and generate relevant data outputs for analysis

Preferred qualifications:  

  • At least two years’ experience between academic or industry research
  • Ability to assist in the design of experiments and interpretation of results
  • Technical proficiency with designing and executing qPCR and qRT-PCR assays
  • Familiarity with general biochemistry techniques, such as protein expression and purification, Western blotting
  • Experience with genetically intractable or difficult-to-culture bacterial organisms
  • Experience with computational tools analyzing communities of microbes (16S, whole genome sequencing, metagenome sequencing, transcriptome sequencing, RNAseq) is highly desirable

Job Type: Full-time

Job Location: Research Triangle Park, North Carolina

For immediate consideration, please email your resume or CV to: careers@locus-bio.com

Direct applicants only. No agencies please.